MOMA's research program is anchored at the Department of Clinical Medicine, Aarhus University, and Aarhus University Hospital.
The list below contains a selection of larger projects and research networks.


A randomized controlled trial investigating the benefit of plasma ctDNA guided postoperative surveillance of patients resected (R0/R1) for stage I, II and III PDAC compared to the current standard-of-care surveillance

Population:      Patients resected with curative intend for stage I, II and III pancreatic cancer
Sample size:    410

Consortium CellX

CellX - The Danish Single Cell Examination Platform

Consortium PCAWG

Pan-Cancer Analysis of Whole Genomes (PCAWG)

Danish National Center for Circulating Tumor DNA Guided Cancer Treatment (ctDNA Center)

The DCCC ctDNA Research Center is a national founded research center for ctDNA guided cancer treatment. We develop clinical protocols and provide critical infrastructure for conducting ctDNA guided treatments trials. The objective of the center is to provide a framework for faster clinical implementation of ctDNA guided treatment decisions.
The center is managed by Center Director Professor Claus Lindbjerg Andersen and Center Vice Director Professor Lars Dyrskjøt Andersen.


A prospective observational study exploring the prognostic and predictive value of measuring ctDNA prior to and after curative intended treatment, and during postoperative surveillance.

Population:   Stage I-III colorectal cancer patients
Sample size:  2500 NCT03748680


A randomized trial investigating if treating postoperative ctDNA positive patients standard adjuvant chemotherapy therapy improves the disease free survival, compared to the standard of care surveillance.

Population:   Stage I-II ctDNA positive colorectal cancer patients
Sample size:  36 NCT03748680


A randomized controlled trial investigating the benefit of ctDNA guided postoperative surveillance compared to the current standard-of-care CT-scan surveillance for patients with colorectal cancer.

Population:      Adjuvant chemotherapy treated stage II high risk and stage III colorectal cancer patients
Sample size:    310 NCT04084249


A prospective randomized trial investigating the effect of RFA-mediated immune-stimulation in patients undergoing curative-intent surgery for CRLM, compared to current standard-of-care. The study also explores the utility of using ctDNA as a biomarker for prediction of incipient recurrence.

Population:      Patients treated with curative intend for colorectal liver metastases
Sample size:    220 NCT04798898

Nordic-SUN trial

A Multicenter Randomized trial of deferred cytoreductive nephrectomy in synchronous metastatic renal cell carcinoma receiving checkpoint inhibitors: a DaRenCa and NoRenCa trial evaluating the impact of surgery versus no surgery.
Niels Fristrup is the Principal Investigator.

Population:      Patients with synchronous metastatic renal cell carcinoma

Sample size:    400 NCT03977571

Novo Nordisk Fondens Data Science Collaborative Research Programme 2021

Mutational processes in spermatogenesis and their consequences for human health.


The PRACTICAL consortium has pioneered genome wide association studies (GWAS) for prostate cancer.

Pan Prostate Cancer Group (PPCG)

Pan Prostate Cancer Group (PPCG)

Providing breakthrough advances through analysis of a very large series of Whole Genome DNA data from prostate cancer  


Treatment Of Metastatic Bladder Cancer at the Time Of Biochemical reLApse Following Radical Cystectomy
A ctDNA guided intervention trial where we aim to recruit 282 patients with locally advanced bladder cancer. Patients are monitored after cystectomy with ctDNA assays, and treatment with immunotherapy is initiated in ctDNA positive patients. Identifier: NCT04138628


We are very excited to be part of the UK-based TRACERx (Tracking Cancer Evolution Through Therapy) consortium,, led by Professor Charles Swanton at the Francis Crick Institute, London, UK.
Here we particularly contribute to the analysis of ctDNA-based phylogenetic tracking of cancer evolution during therapy.

Turner Syndrome Guideline Group

A three year developmental process with the aim of introducing new international clinical care guidelines for Turner syndrome.

An international meeting with delegates from all five continents is planned to take place in Aarhus, Denmark in June 2023, followed by writing of the guidelines.

UROMOL Consortium

A prospective European multi-center study of patients diagnosed with early-stage bladder cancer to identify and validate prognostic biomarkers in urine, tissue, and blood samples. A particular focus has been to delineate gene expression signatures for predicting disease outcome and to establish risk scores for outcome combining molecular markers and clinical risk factors. The consortium has been active since 2008.